Reglan (Metoclopramide) Guide: Uses, Dosage, Side Effects & Safety

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TL;DR:

• Reglan is the brand name for metoclopramide, a prescription drug that boosts stomach emptying and eases nausea.
• Typical adult dose is 10mg taken 30minutes before meals, up to 4 times a day, but follow your doctor’s plan.
• Common side effects include drowsiness, fatigue, and mild diarrhea; serious reactions are rare but need prompt medical attention.
• Never use it longer than 12 weeks without a doctor’s review because of a small risk of movement disorders.
• Keep a symptom diary, stay hydrated, and discuss any other meds you take to avoid interactions.

What is Reglan and How Does It Work?

Reglan is the trade name for metoclopramide, a drug that belongs to the class of pro‑kinetic agents. In plain terms, it helps the gut move food along faster and blocks signals that trigger nausea and vomiting.

The medication works on two fronts:

1. Boosts stomach contractions: It stimulates the upper GI tract, which can be a lifesaver for people with gastroparesis (slow stomach emptying).
2. Blocks dopamine receptors in the brain’s chemoreceptor trigger zone, reducing the urge to vomit.

Because it hits both the gut and the brain, doctors prescribe it for a range of issues: morning sickness, post‑surgical nausea, chemotherapy‑induced vomiting, and the uncomfortable bloating that comes with delayed stomach emptying.

In the UK, Reglan is a prescription‑only medicine, and the NHS typically limits its use to short‑term courses unless a specialist says otherwise.

When and How to Take Reglan Safely

Before you start, get a written plan from your GP or specialist. The typical adult schedule looks like this:

• Take 10mg (usually one tablet) 30minutes before each meal and at bedtime.
• Maximum of 40mg per day (four doses).
• Short‑term use: 2‑4 weeks for nausea, up to 12 weeks for gastroparesis.

Here’s a quick cheat‑sheet for timing:

Key safety pointers:

• Do not crush or chew the tablet - swallow it whole to ensure proper absorption.
• Stay upright for at least 30minutes after taking the dose; lying down can increase reflux.
• Avoid alcohol; it heightens drowsiness and dizziness.
• If you miss a dose, take it as soon as you remember unless it’s less than 4hours before the next scheduled dose. In that case, skip it - don’t double up.

Special groups need extra caution:

• Pregnant women: Only use if the benefits outweigh risks, typically in the second trimester for severe morning sickness.
• Elderly: Start with a lower dose (5mg) because they’re more prone to side effects like confusion.
• People with Parkinson’s disease: Avoid, as blocking dopamine can worsen motor symptoms.

Common Side Effects and When to Call the Doctor

Most people tolerate Reglan well, but you should know what to expect. The side‑effect profile falls into two buckets: mild and serious.

Mild, often temporary:

• Drowsiness or fatigue - happens in about 10‑15% of users.
• Dry mouth, constipation, or mild diarrhea.
• Restless‑leg‑type sensations - usually resolve after a few days.

Serious, though rare:

• Extrapyramidal symptoms (EPS) - muscle stiffness, tremor, or uncontrollable movements. The risk rises after 4‑6 weeks of continuous use.
• Neuroleptic malignant syndrome - a medical emergency marked by high fever, muscle rigidity, and confusion.
• Severe depression or suicidal thoughts - watch for mood changes, especially if you have a history of mental health issues.

If you notice any of the serious signs, stop the medication and seek urgent care. For milder symptoms, talk to your pharmacist; they may suggest taking the dose with food or adjusting the timing.

One practical tip: keep a symptom journal. Note the dose, time, and any side effects. This record helps your doctor decide whether to taper the drug or switch to an alternative.

FAQs and Practical Tips

Below are the most common questions people ask after getting a prescription for Reglan.

Can I use Reglan for motion sickness?

It’s not the first‑line choice. Over‑the‑counter antihistamines work better for most travellers. Reglan is usually reserved for stronger, medication‑induced nausea.

What should I do if I feel dizzy while driving?

Do not drive or operate heavy machinery until you know how the drug affects you. Dizziness peaks about 1‑2hours after taking a dose.

Is it safe to combine Reglan with antidepressants?

Some antidepressants (especially SSRIs and SNRIs) can raise the risk of serotonin syndrome when mixed with metoclopramide. Always list every medication you take to your prescriber.

Can I take Reglan with other stomach drugs like antacids?

Yes, but separate the doses by at least 2hours to avoid absorption interference.

Why does my doctor want me to stop after 12 weeks?

Long‑term use slightly increases the chance of movement disorders, which can be irreversible. The doctor will reassess your symptoms and may switch you to a different pro‑kinetic if needed.

Final tip: store Reglan at room temperature, away from moisture and heat. Keep it out of reach of children - it’s a prescription drug, not a toy.

If you’ve followed the dosing guide, watched for side effects, and keep an open line with your healthcare provider, you’ll get the most benefit from Reglan with minimal risk.